The Caffeine Metabolism DNA Test evaluates an individual’s rate of metabolizing caffeine.

Nausea, vomiting and diarrhea, gastritis or insomnia and tachycardia are just some of the symptoms of caffeine intolerance. In general, the intestine is the organ that most likely indicates a possible allergy or intolerance to caffeine.

Although the symptoms of intolerance are less serious than those of an allergy, in the vast majority of cases, it is best not to ignore caffeine intolerance because in the long run it can worsen and lead to more serious symptoms.

Don’t worry, knowing your body is only the first step in the new path to wellness. The test is able to identify whether you are a slow or rapid metabolizer.

Slow metabolizers should limit or eliminate caffeine intake because they are more susceptible to hypertension, while rapid metabolizers can have caffeine and are actually more protected from this risk with its intake.

The correlation with hypertension is positive and linear with respect to the quantity of coffee consumed for slow metabolizers, while rapid metabolizers have an inverse correlation, therefore for them the intake of 4 or more coffees per day for example is actually protective with respect to the risk of hypertension.

Genetic analysis involves examining the gene CYP1A2.

The CYP1A2 gene encodes the cytochrome P450 protein CYP1A2, which is the primary enzyme involved in caffeine metabolism in the liver. Caffeine exerts its primary biological effects in the central nervous system by acting as an antagonist to adenosine, a neurotransmitter responsible for the feeling of tiredness we experience when we are not rested.

The unfavorable variant of the gene for the enzyme causes slow metabolization of caffeine, which consequently prolongs its effects and can increase the risk of developing hypertension.

The indication of susceptibility is based on scientific evidence that associates the unfavorable allelic variants detected by the analysis with an increase in the subject’s susceptibility compared to the general population. This increase in susceptibility is a probabilistic measure, because it does not take into account the subject’s lifestyle but only his genetic makeup. Therefore, it is not a diagnosis and it does not imply a cause-effect relationship.

For an example of a report and related recommendations to follow, please click here:

A DNA test for caffeine metabolism does not require you to provide a blood sample. Our test is performed using buccal swabs that we provide in our home sample collection kit. Collecting samples is quick and easy, as long as you follow the instructions provided carefully.

Sample collection instructions can be found on our “How to Collect DNA Samples” page.

Please read our terms and conditions for clinical and health-related testing carefully and make sure you understand them before placing an order.

Please contact us with any questions or to place an order.

We also offer tests to determine your predisposition to disease, celiac disease and lactose intolerance. For more information please click here.

If you’re interested in how your genes impact more than just caffeine metabolism, you might want to explore our Sport DNA Test, which can reveal your ideal sport and even provide a personalized training plan based on your genetic profile.

Disclaimer: Test results are for informational and/or educational purposes only and should NOT be used to make medical, health or other decisions without consulting a physician. Always talk to your physician and seek professional help before taking action. This test is not a substitute for a visit to a physician, or the advice or services of a physician or other qualified healthcare professional.

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